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class=\"wp-block-paragraph\">\u7814\u7a76\u5df2\u8b49\u5be6\uff0c\u8178\u9053\u83cc\u7fa4\u5931\u8abf\u53ef\u80fd\u5f71\u97ff\u5168\u8eab\u591a\u500b\u5668\u5b98\u7684\u764c\u75c7\u767c\u751f\u548c\u767c\u5c55\uff0c\u5305\u62ec\u7d50\u76f4\u8178\u764c\uff08Song\u7b49\u4eba\uff0c2020\u5e74\uff1bHelmink\u7b49\u4eba\uff0c2019\u5e74\uff09\u3002\u5118\u7ba1\u7522\u6c2b\u83cc\u548c\u6d88\u6c2b\u83cc\u6db5\u84cb\u4e86\u5927\u90e8\u5206\u8178\u9053\u83cc\u7fa4\uff0c\u4f46\u5176\u4e2d\u6240\u542b\u83cc\u7fa4\u7684\u5177\u9ad4\u5f62\u614b\u548c\u4ee3\u8b1d\u65b9\u5f0f\u5dee\u7570\u5f88\u5927\uff0c\u4e14\u7f3a\u4e4f\u9069\u7576\u7684\u5206\u985e\u5b78\uff0c\u56e0\u6b64\u76f4\u63a5\u7814\u7a76\u8178\u9053\u6c2b\u6c23\u4ee3\u8b1d\u8207\u764c\u75c7\u4e4b\u9593\u7684\u95dc\u4fc2\u7684\u6587\u7ae0\u5f88\u5c11\u3002\u4e00\u4e9b\u7814\u7a76\u8abf\u67e5\u4e86\u6c2b\u5316\u9176\u7684\u57fa\u56e0\u7d44\u548c\u5143\u57fa\u56e0\u7d44\u5206\u4f48\uff0c\u9019\u662f\u50ac\u5316\u6c2b\u6c23\u6c27\u5316\u548c\u91cb\u653e\u7684\u53ef\u9006\u9176\uff0c\u4ee5\u66f4\u6df1\u5165\u5730\u4e86\u89e3\u6c2b\u6c23\u4ee3\u8b1d\u5c0d\u8178\u9053\u751f\u614b\u7cfb\u7d71\u7684\u8ca2\u737b\uff08Greening\u7b49\u4eba\uff0c2016\u5e74\uff1bPeters\u7b49\u4eba\uff0c2015\u5e74\uff1bSuzuki\u7b49\u4eba\uff0c2018\u5e74\uff09\u3002\u6839\u64da\u7d50\u5408\u91d1\u5c6c\u8f14\u56e0\u5b50\uff0cGreening\u7b49\u4eba\u9452\u5b9a\u4e864\u7d44\uff0822\u500b\u4e9e\u7d44\uff09[NiFe] 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class=\"wp-block-paragraph\">\u7136\u800c\uff0c\u5f88\u5bb9\u6613\u767c\u73fe\uff0c\u8178\u9053\u83cc\u7fa4\u7522\u751f\u7684\u6c2b\u6c23\u53ef\u4ee5\u53c3\u8207\u8abf\u7bc0\u8207\u764c\u75c7\u767c\u751f\u76f8\u95dc\u7684\u5404\u7a2e\u83cc\u7fa4\u4ee3\u8b1d\u7269\uff08Ge\u7b49\u4eba\uff0c2022\u5e74\uff1bFan\u548cPedersen\uff0c2021\u5e74\uff1bKalantar-Zadeh\u7b49\u4eba\uff0c2019\u5e74\uff09\uff0c\u4f8b\u5982\u6c2b\u6c23\u53ef\u4ee5\u6e05\u9664\u6d3b\u6027\u6c27\u7269\u7a2e\u4e26\u4fc3\u9032\u77ed\u93c8\u8102\u80aa\u9178\uff08SCFAs\uff09\u7684\u7522\u751f\u3002\u4f8b\u5982\uff0c\u4e00\u9805\u7814\u7a76\u8868\u660e\uff0c\u5c07HRW\u53e3\u670d\u7d66\u5c0f\u9f20\u53ef\u4ee5\u901a\u904e\u8abf\u7bc0\u8178\u9053\u83cc\u7fa4\u7684\u7d44\u6210\u4fc3\u9032\u76f2\u8178\u5167\u5bb9\u7269\u548c\u5faa\u74b0\u4e2dSCFAs\u7684\u7522\u751f\uff08Higashimura\u7b49\u4eba\uff0c2018\u5e74\uff09\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u9ad8\u786b\u9178\u9e7d\u9084\u539f\u83cc\uff08SRB\uff09\u548c\u542b\u786b\u86cb\u767d\u8cea\u7684\u98f2\u98df\u8207\u7d50\u8178\u764c\u7684\u767c\u5c55\u6709\u95dc\uff08Nguyen\u7b49\u4eba\uff0c2020\u5e74\uff1bLee\u7b49\u4eba\uff0c2022\u5e74\uff09\uff0c\u9019\u53ef\u4ee5\u901a\u904e\u7522\u751f\u786b\u5316\u6c2b\u4f86\u7834\u58de\u7d30\u80de\u8272\u7d20\u6c27\u5316\u9176\u3001\u6291\u5236\u4e01\u9178\u5229\u7528\u3001\u963b\u7919\u9ecf\u6db2\u5408\u6210\u4e26\u901a\u904eDNA\u7532\u57fa\u5316\u5f15\u8d77\u3002\u6b64\u5916\uff0c\u8178\u9053\u83cc\u7fa4\u904e\u91cf\u7522\u751f\u7684\u786b\u5316\u6c2b\u5728\u8178\u9053\u816b\u7624\u7684\u767c\u751f\u548c\u767c\u5c55\u4e2d\u767c\u63ee\u8457\u91cd\u8981\u4f5c\u7528\uff08Ngowi\u7b49\u4eba\uff0c2021\u5e74\uff1bAttene-Ramos\u7b49\u4eba\uff0c2010\u5e74\uff1bDalal\u7b49\u4eba\uff0c2021\u5e74\uff09\u3002\u77db\u76fe\u7684\u662f\uff0c\u5404\u7a2e\u542b\u786b\u98f2\u98df\u9577\u671f\u4ee5\u4f86\u90fd\u88ab\u8b49\u660e\u5177\u6709\u6297\u816b\u7624\u7279\u6027\uff0c\u5982\u5927\u849c\u548c\u5341\u5b57\u82b1\u79d1\u852c\u83dc\uff08Rose\u7b49\u4eba\uff0c2021\u5e74\uff1bAbbaoui\u7b49\u4eba\uff0c2018\u5e74\uff09\u3002\u6211\u5011\u8a8d\u70ba\u90e8\u5206\u539f\u56e0\u662f\u5728\u9019\u4e9b\u4e0d\u540c\u7684\u98f2\u98df\u74b0\u5883\u4e2d\uff0cSRB\u8207\u5176\u4ed6\u6c2b\u4ee3\u8b1d\u83cc\u7fa4\u5728\u8154\u5167\u7684\u5e73\u8861\u3002\u6b64\u5916\uff0cSRB\u4ee3\u8b1d\u7684\u6c2b\u6c23\u548c\u786b\u5316\u6c2b\u4e4b\u9593\u7684\u5e73\u8861\u53ef\u80fd\u662f\u6f5b\u5728\u6a5f\u5236\uff08\u898b\u5716\u4e00\uff09\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/ibeauty.media\/wp-content\/uploads\/2024\/04\/Screenshot_20240411_091907_Microsoft-365-Office.jpg\" alt=\"\" class=\"wp-image-208107\"\/><figcaption class=\"wp-element-caption\">\u5716\u4e00<\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u8178\u9053\u83cc\u7fa4\u4e2d\u7684\u6c2b\u6c23\u4ee3\u8b1d\u8abf\u7bc0\u8457\u8178\u9053\u5065\u5eb7<\/strong><\/p>\n\n\n\n<p 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\u8178\u9053\u83cc\u7fa4\u7522\u751f\u7684\u6c2b\u6c23\u80fd\u5920\u7dad\u6301\u5e73\u8861\u3002<strong>\u8178\u9053\u4e2d\u7684\u6c2b\u6c23\u4ee3\u8b1d\u4e0d\u50c5\u5c0d\u8178\u9053\u5065\u5eb7\u81f3\u95dc\u91cd\u8981\uff0c\u800c\u4e14\u5c0d\u591a\u500b\u5668\u5b98\u7684\u6c27\u5316\u9084\u539f\u5e73\u8861\u548c\u514d\u75ab\u5e73\u8861\u81f3\u95dc\u91cd\u8981\uff08\u898b\u5716\u4e8c\uff09\u3002<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/ibeauty.media\/wp-content\/uploads\/2024\/04\/Screenshot_20240411_091956_Microsoft-365-Office.jpg\" alt=\"\" class=\"wp-image-208108\"\/><figcaption class=\"wp-element-caption\">\u5716\u4e8c<\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u8178\u9053\u83cc\u7fa4\u7522\u751f\u7684\u6c2b\u6c23\u7dad\u8b77\u591a\u7cfb\u7d71\u5065\u5eb7\u548c\u514d\u75ab\u5e73\u8861<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u8178\u9053\u7522\u751f\u7684\u6c2b\u6c23\u53ef\u4ee5\u7a7f\u900f\u8179\u8154\u6216\u8840\u6db2\uff0c\u5c0d\u5168\u8eab\u591a\u500b\u5668\u5b98\u767c\u63ee\u4fdd\u8b77\u4f5c\u7528\u3002<\/strong>\u53e6\u4e00\u65b9\u9762\uff0c\u6c2b\u6c23\u662f\u8178\u9053\u83cc\u7fa4\u7522\u751f\u77ed\u93c8\u8102\u80aa\u9178\u7684\u5e95\u7269\u3002\u5b83\u4fc3\u9032\u4e86\u77ed\u93c8\u8102\u80aa\u9178\u7684\u7522\u751f\uff0c\u9019\u662f\u8178\u9053\u4e0a\u76ae\u7d30\u80de\u548c\u514d\u75ab\u7d30\u80de\u7684\u91cd\u8981\u80fd\u91cf\u7269\u8cea\uff0c\u7dad\u8b77\u8178\u9053\u5c4f\u969c\u7684\u5b8c\u6574\u6027\u548c\u5168\u8eab\u514d\u75ab\u7cfb\u7d71\u7684\u7a69\u5b9a\u6027\u3002COPD\uff1a\u6162\u6027\u963b\u585e\u6027\u80ba\u75be\u75c5\uff1bARDS\uff1a\u6025\u6027\u547c\u5438\u7a98\u8feb\u7d9c\u5408\u75c7\uff1bSCFA\uff1a\u77ed\u93c8\u8102\u80aa\u9178&nbsp;&nbsp; &nbsp; 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class=\"wp-block-paragraph\">\u5728\u7537\u6027\u548c\u5973\u6027\u5668\u5b98\u4e2d\uff0c\u5982\u777e\u4e38\u548c\u5375\u5de2\uff0c\u5728\u5c0e\u81f4\u529f\u80fd\u969c\u7919\u7684\u640d\u50b7\u5f8c\uff0c\u6c2b\u6c23\u88dc\u5145\u53ef\u4ee5\u6709\u6548\u6e1b\u5c11\u6c27\u5316\u58d3\u529b\u4e26\u4fc3\u9032\u5668\u5b98\u529f\u80fd\u7684\u6062\u5fa9\u3002\u5118\u7ba1\u8a31\u591a\u7814\u7a76\u96c6\u4e2d\u5728\u5916\u6e90\u6027\u6c2b\u6c23\u88dc\u5145\u4e0a\uff0c\u4f46\u8178\u9053\u4e2d\u7684\u6c2b\u6c23\u7522\u751f\u8207\u6c2b\u6c23\u5438\u5165\u548c\u53e3\u670d\u6c2b\u6c23\u5bcc\u542b\u6c34\u540c\u6a23\u6709\u6548\u5730\u63d0\u9ad8\u4e86\u9ad4\u5167\u7684\u6c2b\u6c23\u6c34\u5e73\u3002\u4f8b\u5982\uff0c\u679c\u7cd6\u7684\u7d66\u4e88\u53ef\u4fc3\u9032\u8179\u8154\u6c2b\u6c23\u6fc3\u5ea6\u589e\u52a011\u500d\uff0c\u4e26\u5728\u8840\u6db2\u7cfb\u7d71\u4e2d\u986f\u8457\u589e\u52a0\u6c2b\u6c23\uff08\u897f\u6751\u7b49\u4eba\uff0c2013\u5e74\uff09\u3002<\/p>\n\n\n\n<p 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class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/ibeauty.media\/wp-content\/uploads\/2024\/04\/Screenshot_20240411_092506_Microsoft-365-Office.jpg\" alt=\"\" class=\"wp-image-208109\"\/><figcaption class=\"wp-element-caption\">\u5716\u4e09<\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">H2\u5728\u6297\u6c27\u5316\u58d3\u529b\u4e2d\u7684\u6a5f\u5236\u3002SOD\uff1a\u8d85\u6c27\u5316\u7269\u6b67\u5316\u9176\uff1bCAT\uff1a\u904e\u6c27\u5316\u6c2b\u9176\uff1bGPx\uff1a\u8c37\u80f1\u7518\u80bd\u904e\u6c27\u5316\u7269\u9176\uff1bHO-1\uff1a\u8840\u7d05\u7d20\u6c27\u5316\u91761\uff1bMPO\uff1a\u9ad3\u904e\u6c27\u5316\u7269\u9176\uff1bGSS\uff1a\u8c37\u80f1\u7518\u80bd\u5408\u6210\u9176\uff1bMAPK\uff1a\u6709\u4e1d\u5206\u88c2\u539f\u6d3b\u5316\u86cb\u767d\u6fc0\u9176\uff1bJNK\uff1ac-Jun 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class=\"wp-block-paragraph\">\u8a31\u591a\u81e8\u5e8a\u8a66\u9a57\u5df2\u78ba\u8a8d\u4e86H2\u5728\u8abf\u7bc0\u764c\u75c7\u514d\u75ab\u4e2d\u7684\u4f5c\u7528\u3002\u4e00\u9805\u65bc2018\u5e74\u9032\u884c\u7684\u81e8\u5e8a\u7814\u7a76\u6d89\u53ca55\u4f8b\u7b2c\u56db\u671f\u7d50\u8178\u764c\u60a3\u8005\uff0c\u7d50\u679c\u986f\u793aH2\u5438\u5165\u964d\u4f4e\u4e86\u60a3\u8005\u5916\u5468\u8840\u4e2dCD8+T\u7d30\u80de\u4e0aPD-1\u7684\u8868\u9054\uff0c\u6e1b\u5c11\u4e86CD8+T\u7d30\u80de\u7684\u640d\u8017\uff0c\u4e26\u6539\u5584\u4e86\u9810\u5f8c\uff08Akagi\u548cBaba\uff0c2019\uff09\u3002\u5728\u4e00\u9805\u81e8\u5e8a\u4e0a\u9032\u884c\u7684\u665a\u671f\u5c0f\u7d30\u80de\u80ba\u764c\u7814\u7a76\u4e2d\uff0c\u9023\u7e8c\u5438\u5165H2 2\u9031\u53ef\u9006\u8f49\u60a3\u8005\u5916\u5468\u8840\u4e2d\u5167\u5728\u548c\u9069\u61c9\u6027\u514d\u75ab\u7cfb\u7d71\u7684\u58d3\u5236\uff0c\u6e1b\u5c11\u4e86\u8017\u7aed\u7684CD8+T\u7d30\u80de\uff0c\u4e26\u5c07\u529f\u80fd\u6027CD4+\u3001CD8+T\u7d30\u80de\u548c\u81ea\u7136\u6bba\u50b7\u7d30\u80de\u6bd4\u7387\u6062\u5fa9\u5230\u6b63\u5e38\u6c34\u5e73\uff08Chen\u7b49\uff0c2020\uff09\u3002\u96d6\u7136\u5f88\u5c11\u6709\u7814\u7a76\u63a2\u8a0e\u5176\u6f5b\u5728\u6a5f\u5236\uff0c\u4f46\u9078\u64c7\u6027\u6e05\u9664\u6709\u6bd2ROS\u4e26\u4fdd\u8b77T\u7d30\u80de\u7c92\u7dda\u9ad4\u53ef\u80fd\u662fH2\u514d\u75ab\u4fdd\u8b77\u529f\u80fd\u7684\u6838\u5fc3\u6a5f\u5236\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u6297\u539f\u5448\u5473\u7d30\u80de\u6297\u539f\u6fc0\u6d3bT\u7d30\u80de\u53d7\u9ad4\uff08TCR\uff09\u5f8c\uff0c\u4e0b\u6e38\u4fe1\u865f\u8f49\u5c0e\u589e\u5f37\u4e86\u7c92\u7dda\u9ad4\u4ee3\u8b1d\uff0cROS\u4f5c\u70ba\u7c92\u7dda\u9ad4\u4ee3\u8b1d\u7684\u660e\u986f\u526f\u7522\u7269\uff0c\u662f\u8abf\u7bc0T\u7d30\u80de\u4ee3\u8b1d\u91cd\u7d44\u7684\u591a\u500b\u6838\u5fc3\u9014\u5f91\u4e2d\u7684\u91cd\u8981\u5206\u5b50\uff08Franchina\u7b49\uff0c2018\u5e74\uff1bFranco\u7b49\uff0c2020\u5e74\uff09\u3002\u7136\u800c\uff0c\u5982\u524d\u6240\u8ff0\uff0c\u904e\u5ea6\u751f\u9577\u7684\u764c\u7d30\u80de\u53ef\u80fd\u5c0e\u81f4\u764c\u7d30\u80de\u5fae\u74b0\u5883\u4e2d\u7684ROS\u5347\u9ad8\uff0c\u7576T\u7d30\u80de\u88ab\u6fc0\u6d3b\u6642\uff0c\u7c92\u7dda\u9ad4\u7522\u751f\u9ad8ROS\uff0c\u52a0\u4e0aT\u7d30\u80de\u7531\u65bc\u7f3a\u6c27\u7b49\u56e0\u7d20\u5c0e\u81f4ROS\u589e\u52a0\uff08Scharping\u7b49\uff0c2021\u5e74\uff09\uff0c\u9019\u4f7f\u5f97\u6d78\u6f64\u816b\u7624\u7684\u6dcb\u5df4\u7d30\u80de\uff08TILs\uff09\u5728\u6fc0\u6d3b\u6642\u9762\u81e8\u66f4\u9ad8\u6c34\u5e73\u7684ROS\u751f\u7406\u72c0\u614b\uff08Franco\u7b49\uff0c2020\u5e74\uff09\u3002\u6301\u7e8c\u9ad8\u6c34\u5e73\u7684ROS\u7834\u58deT\u7d30\u80de\u7c92\u7dda\u9ad4\uff0c\u6291\u5236T\u7d30\u80de\u6fc0\u6d3b\uff0c\u4e26\u901a\u904e\u504f\u96e2T\u7d30\u80de\u4ee3\u8b1d\u91cd\u7d44\u5c0e\u81f4T\u7d30\u80de\u529f\u80fd\u5931\u8abf\uff08Laura\uff0c2012\u5e74\uff1bScharping\u7b49\uff0c2016\u5e74\uff09\uff0c\u4e26\u4fc3\u9032PD-1\u7684\u8868\u9054\u4ee5\u8a98\u5c0e\u51cb\u4ea1\uff08Najjar\u7b49\uff0c2019\u5e74\uff09\uff08\u898b\u57164\uff09\u3002\u53e6\u4e00\u65b9\u9762\uff0cH2\u5728\u5404\u7a2e\u75be\u75c5\u689d\u4ef6\u4e0b\u5c0d\u6297\u6c27\u5316\u58d3\u529b\u4e26\u901a\u904e\u8abf\u7bc0NADH\/NADPH\u9014\u5f91\u6062\u5fa9\u4e86\u9ad4\u5167\u74b0\u5883\u7684\u6c27\u5316\u9084\u539f\u5e73\u8861\uff0c\u5f9e\u800c\u4fdd\u8b77\u4e86T\u7d30\u80de\u7684\u6fc0\u6d3b\u4e26\u9632\u6b62\u4e86\u51cb\u4ea1\u3002\u6b64\u5916\uff0c\u5728\u9019\u7a2e\u60c5\u6cc1\u4e0b\uff0c\u8207\u5e38\u898f\u7684\u6297\u816b\u7624\u85e5\u7269\u76f8\u6bd4\uff0cH2\u7684\u9ad8\u6ef2\u900f\u6027\u4f7f\u5176\u80fd\u5920\u8f15\u9b06\u6ef2\u900f\u5230\u816b\u7624\u5167\u90e8\uff0c\u751a\u81f3\u9032\u5165TILs\u7684\u7c92\u7dda\u9ad4\u7d50\u69cb\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/ibeauty.media\/wp-content\/uploads\/2024\/04\/Screenshot_20240411_092726_Microsoft-365-Office.jpg\" alt=\"\" class=\"wp-image-208110\"\/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>H2\u901a\u904e\u9078\u64c7\u6027\u6e05\u9664\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u7684ROS\u4f86\u767c\u63ee\u6297\u816b\u7624\u6d3b\u6027\u3002<\/strong>ROS\u53ef\u4ee5\u901a\u904e\u640d\u5bb3DNA\u3001\u5c0e\u81f4\u57fa\u56e0\u7a81\u8b8a\u4ee5\u53ca\u8abf\u7bc0\u5404\u7a2e\u95dc\u9375\u7684\u4fe1\u865f\u50b3\u5c0e\u9014\u5f91\u4f86\u5f15\u767c\u816b\u7624\u767c\u751f\u548c\u8f49\u79fb\u3002\u816b\u7624\u5fae\u74b0\u5883\u4e2d\u7684ROS\u53ef\u4ee5\u6ef2\u900f\u5230T\u7d30\u80de\u4e2d\uff0c\u589e\u52a0\u6301\u7e8c\u6d3b\u5316T\u7d30\u80de\u7684\u6c27\u58d3\u8ca0\u64d4\u3002T\u7d30\u80de\u4e2d\u904e\u591a\u7684ROS\u53ef\u4ee5\u5e72\u64fe\u7c92\u7dda\u9ad4\u80fd\u91cf\u4ee3\u8b1d\uff0c\u640d\u50b7T\u7d30\u80deDNA\uff0c\u4e26\u4fc3\u9032PD-1\u7684\u8868\u9054\uff0c\u5c0e\u81f4T\u7d30\u80de\u529f\u80fd\u969c\u7919\u548c\u51cb\u4ea1\u3002ROS\uff1a\u6d3b\u6027\u6c27\u7269\u7a2e\uff1bEMT\uff1a\u4e0a\u76ae\u9593\u8cea\u8f49\u5316\uff1bTeff\uff1a\u6548\u61c9\u6027T\u7d30\u80de\uff1bTex\uff1a\u8017\u7aedT\u7d30\u80de\u3002NF-\u03baB\uff1a\u6838\u56e0\u5b50\u03baB\uff1bMAPK\uff1a\u4e26\u767c\u6fc0\u6d3b\u86cb\u767d\u6fc0\u9176\uff1bmTORC1\uff1a\u96f7\u5e15\u9ef4\u9709\u7d20\u9776\u6a19\u86cb\u767d\u8907\u5408\u72691 \u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">H2\u5728\u6297\u6c27\u5316\u5e94\u6fc0\u4e2d\u7684\u4f5c\u7528\u6a5f\u5236\u3002\u7531\u65bc\u7dda\u7c92\u9ad4\u547c\u5438\u93c8\u662f\u7d30\u80de\u4e2dROS\u751f\u6210\u7684\u4e3b\u8981\u4f86\u6e90\uff0c\u5c40\u90e8\u9ad8\u6fc3\u5ea6\u7684ROS\u53ef\u80fd\u5c0e\u81f4\u7dda\u7c92\u9ad4DNA\u7684\u7a81\u8b8a\u548c\u76f4\u63a5\u7834\u58de\u7dda\u7c92\u9ad4\u52d5\u529b\u5b78\uff0c\u6700\u7d42\u5c0e\u81f4\u7dda\u7c92\u9ad4\u4ee3\u8b1d\u529f\u80fd\u969c\u7919\uff08Deng et al. 2020\uff09\u548cT\u7d30\u80de\u51cb\u4ea1\uff08Scharping et al. 2021\uff09\u3002\u7814\u7a76\u8868\u660e\uff0c\u814e\u7d30\u80de\u764c\u4e2d\u7684TILs\u542b\u6709\u9ad8\u6975\u5316\u3001\u788e\u88c2\u7684\u7dda\u7c92\u9ad4\uff0c\u7522\u751f\u5927\u91cfROS\uff08Siska\u7b49\uff0c2017\uff09\u3002\u8d64\u6728\u7b49\u4eba\u5728\u80ba\u764c\u60a3\u8005\u7684\u81e8\u5e8a\u7814\u7a76\u4e2d\u767c\u73fe\uff08Akagi and Baba 2019, 2020\uff09\uff0cH2\u5438\u5165\u53ef\u589e\u5f37CD8+ T\u7d30\u80de\u7684\u7dda\u7c92\u9ad4\u529f\u80fd\uff0c\u4e26\u964d\u4f4e\u60a3\u8005\u5916\u5468\u8840\u4e2dPD-1\u7684\u8868\u9054\uff0c\u8868\u660eH2\u53ef\u80fd\u901a\u904e\u8abf\u7bc0\u904e\u6c27\u5316\u7269\u9176\u9ad4\u589e\u6b96\u7269\u6fc0\u6d3b\u53d7\u9ad4-\u03b3\u5171\u6fc0\u6d3b\u56e0\u5b50-1\u03b1\uff08PGC-1\u03b1\uff09\u767c\u63ee\u4f5c\u7528\u3002\u83ab\u7b49\u4eba\uff082019\uff09\u63d0\u51fa\uff0c\u5728\u9ad4\u5916H2\u53ef\u4ee5\u9032\u5165\u7dda\u7c92\u9ad4\u4e2d\u4e2d\u548c\u6709\u6bd2ROS\uff0c\u6e1b\u8f15\u7dda\u7c92\u9ad4\u6c27\u5316\u61c9\u6fc0\u640d\u50b7\uff0c\u4fdd\u8b77Na+\/Ka+ ATP\u6cf5\uff0c\u589e\u5f37Bcl-2\u7684\u8868\u9054\uff0c\u6291\u5236\u96fb\u58d3\u4f9d\u8cf4\u6027\u96e2\u5b50\u901a\u90531\uff08VDAC1\uff09\u7684\u8868\u9054\u548c\u958b\u555f\uff0c\u4fdd\u8b77\u7dda\u7c92\u9ad4\u819c\uff0c\u9084\u53ef\u4ee5\u6291\u5236\u534a\u80f1\u6c28\u9178\u5929\u51ac\u91769\u7b49\u51cb\u4ea1\u56e0\u5b50\u7684\u91cb\u653e\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>H2\u5728\u6297\u816b\u7624\u6d3b\u6027\u4e2d\u7684\u61c9\u7528<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5916\u6e90\u6027H2\u7d66\u85e5\uff0c\u5916\u6e90\u6027\u7d66\u85e5H2\u7684\u5e38\u898f\u65b9\u5f0f\u5305\u62ec\u5438\u5165\u3001\u53e3\u670dHRW\u3001\u542bH2\u7684\u9e7d\u6c34\u6ce8\u5c04\u548c\u5916\u7528\uff0c\u4f8b\u5982\u773c\u85e5\u6c34\u548cHRW\u6d74\u3002\u4e00\u4e9b\u7d9c\u8ff0\u6587\u7ae0\u6bd4\u8f03\u4e86\u4e0d\u540cH2\u61c9\u7528\u65b9\u6cd5\u5f15\u8d77\u7684\u4e0d\u540c\u5668\u5b98\u4e2dH2\u6fc3\u5ea6\u589e\u52a0\u901f\u7387\u53ca\u5176\u6cbb\u7642\u6548\u679c\uff0c\u6211\u5011\u5728\u6b64\u4e0d\u9010\u4e00\u5448\u73fe\u3002\u7136\u800c\uff0c\u6211\u5011\u4e0d\u80fd\u7c21\u55ae\u5730\u5c07\u4e0d\u540cH2\u61c9\u7528\u65b9\u6cd5\u5728\u75be\u75c5\u6cbb\u7642\u4e2d\u7684\u4f5c\u7528\u8207\u5faa\u74b0\u548c\u547c\u5438\u7cfb\u7d71\u4e2d\u7684H2\u6fc3\u5ea6\u76f8\u95dc\u806f\uff0c\u4f8b\u5982\uff0cHRW\u5728\u8abf\u7bc0\u8178\u9053\u83cc\u7fa4\u548c\u80fd\u91cf\u4ee3\u8b1d\u65b9\u9762\u7684\u7368\u7279\u4f5c\u7528\u3002<\/p>\n\n\n\n<p 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